Discover the Darker Side of New Orleans with the Pestilence, Pandemic, and Plague Tour

If you’re curious about how disease has shaped New Orleans, this Pestilence, Pandemic, and Plague Tour offers a uniquely eerie glimpse into the city’s history. It’s not your usual sightseeing walk—this tour zeroes in on the outbreaks that left their mark on the French Quarter, highlighting stories often buried in history books. It’s a guided experience that mixes fascinating medical stories with tales of voodoo, religion, and the city’s response to crises over the centuries.
What really catches our eye about this tour are two things: the depth of knowledge from guides and the surprisingly good value at just $37 per person. Plus, the fact that it focuses on lesser-known stories means you’ll walk away with a fresh perspective on a city famous for its vibrant culture and haunted tales. On the flip side, a potential consideration is that some reviews mention difficulty hearing the guide at times, so if you’re sensitive to audio, be prepared to listen closely or ask questions.
This tour is especially well-suited for history buffs, medical nerds, or anyone with a fascination for how crises shape societies. If you’re traveling with a curious group seeking something different from the usual jazz or ghost tours, this could be a real highlight of your stay.
Key Points

- Focused on disease history: This tour zeroes in on outbreaks like yellow fever and cholera that influenced the city’s development.
- Knowledgeable guides: Reviewers consistently praise the guides’ expertise and engaging storytelling.
- Balanced pace: The tour length of around 2 hours is just enough to absorb a lot without feeling hurried.
- Accessible sites: Includes prominent landmarks like Jackson Square and the French Quarter.
- Affordable price: At $37 per person, it offers good value for a tour packed with insights.
- Limited capacity: With a maximum of 56 travelers, the group size remains manageable for questions and personal attention.
Planning more time in New Orleans? We've covered other experiences worth considering.
A Detailed Look at the Experience

The Itinerary Breakdown
The tour begins at the New Orleans Pharmacy Museum, which, although it charges an additional admission fee, sets the tone for the tour’s focus on medical history. Here, you’ll get to explore the strange and sometimes creepy methods used in the past to combat pandemics. The museum’s exhibits are a fascinating backdrop, offering a glimpse into early medical practices related to infectious diseases.
Next, the group heads to Jackson Square, the heart of the French Quarter, which has seen its share of plague and pestilence stories. Walking through this historic spot, you’ll hear about how different outbreaks affected the city’s social fabric, with some reviewers mentioning the tour’s storytelling as both engaging and enlightening.
The bulk of the tour takes place across the French Quarter, where the guide points out specific locations tied to historic pandemics and outbreaks. This part lasts about 1 hour and 20 minutes, giving plenty of time to absorb stories and ask questions. The stops are carefully selected to highlight parts of the city that played roles during plague times or significant disease outbreaks.
The Guides and Their Stories
Reviewers consistently rave about the guides’ expertise and charisma. One reviewer mentioned, “Mikko was a fabulous tour guide. He spoke of the city, current and past, and the tour topic—Pestilence, Pandemic, and Plague—throughout New Orleans and US history.” It’s clear that guides are passionate and well-informed, offering insights that go beyond surface-level facts.
Some reviews highlight the guide’s humorous and engaging style, with one saying, “Mikko’s wit and humor make the tour even more enjoyable.” This approach makes complex and sometimes grim topics easier to digest and remember.
What You Can Expect
- In-depth stories about New Orleans’ encounters with yellow fever, cholera, and other diseases.
- Interesting tidbits about how these outbreaks influenced the city’s culture, architecture, and public health responses.
- Historic sites in the French Quarter that played roles during pandemics—some obvious, others more obscure.
- A friendly, guided experience that takes care of directions and offers room for questions.
Considerations and Tips
Some reviewers mention that hearing the guide can be a challenge at times, especially in busy or noisy areas. It’s wise to stay close to the guide and speak up if you’re having trouble catching details. Also, since the tour involves some walking around the French Quarter, comfortable shoes are recommended. The tour lasts about two hours, so moderate physical fitness is ideal.
If you’re visiting during warmer months, remember that the tour is held outdoors. Bring water and wear layers, especially if you’re sensitive to heat or sun exposure.
The Value and Who Should Book
At $37 per person, this tour offers a ton of value, especially considering the depth of knowledge and the unique focus on disease history. It’s a great choice for travelers who want more than just the typical sightseeing experience—those interested in the hidden stories that shaped the city.
If you enjoy learning about history through lively storytelling and are curious about the ways pandemics impacted societies, you’ll probably find this tour fascinating. It’s also suitable for those who like their history with a bit of humor and personality.
While not specifically designed as a family tour, older children with an interest in history or medicine might find it engaging. Just note that the content can be a bit dark and detailed, so use your judgment based on your kids’ interests and sensitivities.
Final Thoughts

This New Orleans Pestilence, Pandemic, and Plague Tour stands out as a unique, informative, and fun way to explore the city’s quieter, darker corners. It offers a balanced mix of storytelling, historical sites, and insightful commentary from guides who clearly love what they do.
If you’re looking for a tour that’s different from the usual, doesn’t break the bank, and provides a good dose of history with some intriguing stories, this could be just the ticket. It’s especially perfect if you have a penchant for medical history or want a more nuanced understanding of how disease has shaped New Orleans through the ages.
For travelers eager to add a layer of depth to their visit, this tour hits the mark—informative, engaging, and well worth the time and price.
New Orleans Pestilence, Pandemic and Plague Tour
“I was lucky enough to end up with a 1:1 tour experience. It was perfectly paced and informative. I work in outbreak response and love medical histo…”
FAQ

How long is the tour?
The tour lasts approximately 2 hours, giving enough time to explore key sites and hear detailed stories without feeling rushed.
Where does the tour start and end?
It begins at 815 Toulouse St and concludes near Bourbon Street & Dumaine Street, within the French Quarter.
Is there an admission fee for the stops?
The New Orleans Pharmacy Museum charges an additional admission fee, but Jackson Square and most stops along the route are free to explore.
What’s included in the price?
The tour includes a professional guide who leads the walk and provides insights into the city’s disease history.
Is the tour suitable for children?
While not specifically marketed as a family tour, children interested in history or medicine might enjoy it. Keep in mind the content can be detailed and somewhat dark.
Can I cancel if I change my mind?
Yes, you can cancel for free up to 24 hours before the start time for a full refund.
Is this tour accessible?
It’s open to service animals and near public transportation, but travelers should have a moderate physical fitness level due to walking involved.
How many people typically join the tour?
The group size is capped at 56 travelers, so it’s not too crowded, providing a more personal experience.
If you’re interested in uncovering the secrets behind New Orleans’ historical pandemics and enjoy guided storytelling, this tour offers insights you won’t find in typical city strolls. It’s a practical, engaging way to deepen your understanding of how disease has influenced and shaped one of America’s most colorful cities.
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- New Orleans Dead of Night Ghosts and Cemetery Bus Tour
- New Orleans History and Hauntings Tour
- New Orleans Zipline Swamp Tour
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- New Orleans Pestilence, Pandemic and Plague Tour
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